反应详情

To a solution of 60 mg (0.176 mmol) 2-benzyloxy-6-methoxy-4-trifluoromethyl-benzoic acid methyl ester in 1 ml ethanol under nitrogen at room temperature, was added 8 mg (0.0071 mmol) Pd/C 10%. The mixture was stirred at room temperature under an hydrogen atmosphere for 4 hours. The catalyst was filtered, washed with dichloromethane and the filtrate was concentrated in vacuo to provide 38 mg (y: 86.1%) of the title compound as a white solid. MS (m/e): 249.0 (M−H).

1. filtrationThe catalyst was filtered
2. washwashed with dichloromethane
3. concentrationthe filtrate was concentrated in vacuo