HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Ethyl-4-(trifluoromethyl)benzoic acid → cis-2-Ethyl-N-(2-pyrrolidin-1-yl-cyclohexyl)-4-trifluoromethyl-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Ethyl-4-(trifluoromethyl)benzoic acid | HCID 53406012 | — |
| Reactant | cis-2-Pyrrolidin-1-yl-cyclohexylamine dihydrochloride | HCID 66680564 | — |
| Product | cis-2-Ethyl-N-(2-pyrrolidin-1-yl-cyclohexyl)-4-trifluoromethyl-benzamide | HCID 51001073 | — |
Reaction Steps
The title compound, white solid, MS: m/e=369.2 [(M+H)+], was prepared in accordance with the general method of example 5 from cis-2-pyrrolidin-1-yl-cyclohexylamine dihydrochloride (intermediate F) and 2-ethyl-4-(trifluoromethyl)-benzoic acid (CAS 854531-63-8).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08404673B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-59dfa195fbcb433e97eed4e0f5f84f20 |
| Source note | uspto-grants-2013_03 |