Cyclopentanone → cis-N-(2-Cyclopentylamino-cyclohexyl)-2-cyclopropyl-4-trifluoromethyl-benzamide

HRID 1950964Notes

Reaction equation

[NH2:1][C@H:2]1[CH2:7][CH2:6][CH2:5][CH2:4][C@H:3]1[NH:8][C:9](=[O:23])[C:10]1[CH:15]=[CH:14][C:13]([C:16]([F:19])([F:18])[F:17])=[CH:12][C:11]=1[CH:20]1[CH2:22][CH2:21]1.[C:24]1(=O)[CH2:28][CH2:27][CH2:26][CH2:25]1>>[CH:24]1([NH:1][C@H:2]2[CH2:7][CH2:6][CH2:5][CH2:4][C@H:3]2[NH:8][C:9](=[O:23])[C:10]2[CH:15]=[CH:14][C:13]([C:16]([F:18])([F:19])[F:17])=[CH:12][C:11]=2[CH:20]2[CH2:22][CH2:21]2)[CH2:28][CH2:27][CH2:26][CH2:25]1

Participants

Reactant 2

HCID 8452Cyclopentanone

HCID 66681224cis-N-(2-Amino-cyclohexyl)-2-cyclopropyl-4-trifluoromethyl-benzamide2×

Product 1

HCID 51000995cis-N-(2-Cyclopentylamino-cyclohexyl)-2-cyclopropyl-4-trifluoromethyl-benzamide

Procedure

The title compound, yellow solid, MS: m/e=395.3 [(M+H)+], was prepared in accordance with the general method of example 11 from cis-N-(2-amino-cyclohexyl)-2-cyclopropyl-4-trifluoromethyl-benzamide (intermediate L) and cyclopentanone.

Sources & evidence

ORD record: ord-280c7327d68f491d94f095d35b44f452
Source dataset: uspto-grants-2013_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08404673B2

Reaction notes

Loading…