N-Acetyl-4-piperidone → HCID 58062935, compound

HRID 1950965Notes

Reaction equation

HRID 1950965 reaction equation
[NH2:1][C@H:2]1[CH2:7][CH2:6][CH2:5][CH2:4][C@H:3]1[NH:8][C:9](=[O:26])[C:10]1[C:15]([C:16]([F:19])([F:18])[F:17])=[CH:14][C:13]([C:20]([F:23])([F:22])[F:21])=[CH:12][C:11]=1[O:24][CH3:25].[C:27]([N:30]1[CH2:35][CH2:34][C:33](=O)[CH2:32][CH2:31]1)(=[O:29])[CH3:28]>>[C:27]([N:30]1[CH2:35][CH2:34][CH:33]([NH:1][C@H:2]2[CH2:7][CH2:6][CH2:5][CH2:4][C@H:3]2[NH:8][C:9](=[O:26])[C:10]2[C:15]([C:16]([F:19])([F:18])[F:17])=[CH:14][C:13]([C:20]([F:21])([F:22])[F:23])=[CH:12][C:11]=2[O:24][CH3:25])[CH2:32][CH2:31]1)(=[O:29])[CH3:28]

Participants

3

Reactant 2

HCID 122563N-Acetyl-4-piperidoneHCID 58062915cis-N-(2-Amino-cyclohexyl)-2-methoxy-4,6-bis-trifluoromethyl-benzamide2×

Product 1

HCID 58062935HCID 58062935, compound

Procedure

The title compound, light yellow solid, MS: m/e=510.4 [(M+H)+], was prepared in accordance with the general method of example 11 from cis-N-(2-amino-cyclohexyl)-2-methoxy-4,6-bis-trifluoromethyl-benzamide (intermediate H) and 1-acetyl-4-piperidone.

Sources & evidence

ORD record
ord-40c460ef575247e68aa5e0845d0a3d00
Source dataset
uspto-grants-2013_03
Patent number
US08404673B2

Reaction notes

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