2-Chloro-3-(trifluoromethyl)benzoic acid → HCID 66681123, compound

HRID 1950984Notes

Reaction equation

HRID 1950984 reaction equation
[N:1]1([C@H:6]2[CH2:10][CH2:9][CH2:8][C@H:7]2[NH2:11])[CH2:5][CH2:4][CH2:3][CH2:2]1.[Cl:12][C:13]1[C:21]([C:22]([F:25])([F:24])[F:23])=[CH:20][CH:19]=[CH:18][C:14]=1[C:15](O)=[O:16]>>[Cl:12][C:13]1[C:21]([C:22]([F:23])([F:24])[F:25])=[CH:20][CH:19]=[CH:18][C:14]=1[C:15]([NH:11][C@@H:7]1[CH2:8][CH2:9][CH2:10][C@@H:6]1[N:1]1[CH2:2][CH2:3][CH2:4][CH2:5]1)=[O:16]

Participants

3

Reactant 2

HCID 27366772-Chloro-3-(trifluoromethyl)benzoic acidHCID 30820884cis-2-Pyrrolidin-1-yl-cyclopentylamine2×

Product 1

HCID 66681123HCID 66681123, compound

Procedure

The title compound, yellow solid, MS: m/e=361.3 [(M+H)+], was prepared in accordance with the general method of example 5 from cis-2-pyrrolidin-1-yl-cyclopentylamine (intermediate Q) and 2-chloro-3-trifluoromethylbenzoic acid.

Sources & evidence

ORD record
ord-a98d1c2dbf1f4d6bacbce66ac407fece
Source dataset
uspto-grants-2013_03
Patent number
US08404673B2

Reaction notes

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