2-Cyclopropyl-4,6-bis-trifluoromethyl-benzoic acid → 2-Cyclopropyl-N-((cis)-2-pyrrolidin-1-yl-cyclohexyl)-4,6-bis-trifluoromethyl-benzamide

HRID 1951012Notes

Reaction equation

HRID 1951012 reaction equation
Cl.Cl.[N:3]1([C@H:8]2[CH2:13][CH2:12][CH2:11][CH2:10][C@H:9]2[NH2:14])[CH2:7][CH2:6][CH2:5][CH2:4]1.[CH:15]1([C:18]2[CH:26]=[C:25]([C:27]([F:30])([F:29])[F:28])[CH:24]=[C:23]([C:31]([F:34])([F:33])[F:32])[C:19]=2[C:20](O)=[O:21])[CH2:17][CH2:16]1>>[CH:15]1([C:18]2[CH:26]=[C:25]([C:27]([F:30])([F:29])[F:28])[CH:24]=[C:23]([C:31]([F:32])([F:33])[F:34])[C:19]=2[C:20]([NH:14][C@@H:9]2[CH2:10][CH2:11][CH2:12][CH2:13][C@@H:8]2[N:3]2[CH2:4][CH2:5][CH2:6][CH2:7]2)=[O:21])[CH2:17][CH2:16]1

Participants

3

Reactant 2

HCID 581677652-Cyclopropyl-4,6-bis-trifluoromethyl-benzoic acidHCID 66680564cis-2-Pyrrolidin-1-yl-cyclohexylamine dihydrochloride2×

Product 1

HCID 510013282-Cyclopropyl-N-((cis)-2-pyrrolidin-1-yl-cyclohexyl)-4,6-bis-trifluoromethyl-benzamide

Procedure

The title compound, white solid, MS: m/e=449.3 [(M+H)+], was prepared in accordance with the general method of example 5 from cis-2-pyrrolidin-1-yl-cyclohexylamine dihydrochloride (intermediate F) and 2-cyclopropyl-4,6-bis-trifluoromethyl-benzoic acid (intermediate AN).

Sources & evidence

ORD record
ord-6a8453afd4eb442284a598958cfad5d7
Source dataset
uspto-grants-2013_03
Patent number
US08404673B2

Reaction notes

Loading…