反应详情

To a solution of rac-[(3S,4R)-4-(3,4-dichloro-phenyl)-1-(4-methanesulfonyl-piperazine-1-carbonyl)-pyrrolidin-3-yl]-methyl-carbamic acid tert-butyl ester (130 mg, 0.24 mmol) in CH2Cl2 (5 ml) was added TFA (1 ml) at RT. Stirring was continued over night. The reaction mixture was then concentrated under vacuo, the crude dissolved in CH2Cl2, washed with aq.NaHCO3 and the organic phase was dried over Na2SO4. Purification by flash chromatography (SiO2, CH2Cl2/MeOH 95:5) yielded 100 mg (92%) of the title compound as light yellow oil. ES-MS m/e: 435.37 (M+H+).

1. waitwas continued over night
2. concentrationThe reaction mixture was then concentrated under vacuo
3. dissolutionthe crude dissolved in CH2Cl2
4. washwashed with aq
5. dry with materialNaHCO3 and the organic phase was dried over Na2SO4
6. customPurification by flash chromatography (SiO2, CH2Cl2/MeOH 95:5)