HRID1951110

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID736133

1-(4-fluorophenyl)cyclopentanecarboxylic acid

C12H13FO2

结构：CNC1CN(C(=O)C2CCN(C(=O)C3(C)CC3)CC2)CC1c1ccc(Cl)c(Cl)c1

HCID67025815

未命名化合物

PRODUCTS

生成物

结构：CN(C(=O)C1(c2ccc(F)cc2)CCCC1)C1CN(C(=O)C2CCN(C(=O)C3(C)CC3)CC2)CC1c1ccc(Cl)c(Cl)c1

HCID67025675

未命名化合物

PROCEDURE

实验过程

In analogy to the procedure described for the synthesis of example 97, the title compound 1-(4-fluoro-phenyl)-cyclopentanecarboxylic acid {(3RS,4SR)-4-(3,4-dichloro-phenyl)-1-[1-(1-methyl-cyclopropanecarbonyl)-piperidine-4-carbonyl]-pyrrolidin-3-yl}-methyl-amide was prepared from {4-[(3SR,4RS)-3-(3,4-dichloro-phenyl)-4-methylamino-pyrrolidine-1-carbonyl]-piperidin-1-yl}-(1-methyl-cyclopropyl)-methanone using 1-(4-fluoro-phenyl)-cyclopentanecarboxylic acid instead of 4-chloro-3-(trifluoromethyl)benzoic acid and was obtained as a light brown oil. MS m/e: 628.3 [M]+.

WORKUP

后处理

customIn analogy to the procedure described for the synthesis of example 97
customwas obtained as a light brown oil

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-740cae31704b4232a8eb61ec0facabce
来源数据集: uspto-grants-2013_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08404679B2
来源说明: uspto-grants-2013_03

反应 SMILES

[Cl:1][C:2]1[CH:3]=[C:4]([CH:9]2[CH:13]([NH:14][CH3:15])[CH2:12][N:11]([C:16]([CH:18]3[CH2:23][CH2:22][N:21]([C:24]([C:26]4([CH3:29])[CH2:28][CH2:27]4)=[O:25])[CH2:20][CH2:19]3)=[O:17])[CH2:10]2)[CH:5]=[CH:6][C:7]=1[Cl:8].[F:30][C:31]1[CH:36]=[CH:35][C:34]([C:37]2([C:42]([OH:44])=O)[CH2:41][CH2:40][CH2:39][CH2:38]2)=[CH:33][CH:32]=1>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:9]2[CH2:10][N:11]([C:16]([CH:18]3[CH2:19][CH2:20][N:21]([C:24]([C:26]4([CH3:29])[CH2:27][CH2:28]4)=[O:25])[CH2:22][CH2:23]3)=[O:17])[CH2:12][CH:13]2[N:14]([CH3:15])[C:42]([C:37]2([C:34]3[CH:33]=[CH:32][C:31]([F:30])=[CH:36][CH:35]=3)[CH2:38][CH2:39][CH2:40][CH2:41]2)=[O:44])[CH:5]=[CH:6][C:7]=1[Cl:8]