2-(4-Fluorophenyl)acetic acid → HCID 67026464, compound

HRID 1951119Notes

Reaction equation

HRID 1951119 reaction equation
[CH2:1]([N:8]1[CH2:12][C@H:11]([C:13]2[CH:18]=[CH:17][C:16]([Cl:19])=[C:15]([Cl:20])[CH:14]=2)[C@@H:10]([NH:21][CH3:22])[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[F:23][C:24]1[CH:29]=[CH:28][C:27]([CH2:30][C:31]([OH:33])=O)=[CH:26][CH:25]=1>>[CH2:1]([N:8]1[CH2:12][CH:11]([C:13]2[CH:18]=[CH:17][C:16]([Cl:19])=[C:15]([Cl:20])[CH:14]=2)[CH:10]([N:21]([CH3:22])[C:31](=[O:33])[CH2:30][C:27]2[CH:26]=[CH:25][C:24]([F:23])=[CH:29][CH:28]=2)[CH2:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 98372-(4-Fluorophenyl)acetic acidHCID 67233833HCID 67233833, compound

Product 1

HCID 67026464HCID 67026464, compound

Procedure

In analogy to the procedure described for the synthesis of example 97, the title compound N-[(3RS,4SR)-1-benzyl-4-(3,4-dichloro-phenyl)-pyrrolidin-3-yl]-2-(4-fluoro-phenyl)-N-methyl-acetamide was prepared from [(3R,4S)-1-benzyl-4-(3,4-dichloro-phenyl)-pyrrolidin-3-yl]-methyl-amine using 4-fluorophenylacetic acid instead of 4-chloro-3-(trifluoromethyl)benzoic acid and was obtained as a light yellow oil. MS m/e: 471.2 [M]+.

Workup

  1. customIn analogy to the procedure described for the synthesis of example 97
  2. customwas obtained as a light yellow oil

Sources & evidence

ORD record
ord-8c3ababfaecd472085945754c0c0481e
Source dataset
uspto-grants-2013_03
Patent number
US08404679B2

Reaction notes

Loading…