HRID1951126

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID20982970

未命名化合物

结构：CN(C(=O)Cc1ccc(F)cc1)C1CNCC1c1ccc(Cl)c(Cl)c1

HCID67025826

未命名化合物

PRODUCTS

生成物

结构：CN(C(=O)Cc1ccc(F)cc1)C1CN(C(=O)c2ccc(N3CCOCC3)nn2)CC1c1ccc(Cl)c(Cl)c1

HCID67025695

未命名化合物

PROCEDURE

实验过程

In analogy to the procedure described for the synthesis of example 87 (step c), the title compound N-[(3RS,4SR)-4-(3,4-dichloro-phenyl)-1-(6-morpholin-4-yl-pyridazine-3-carbonyl)-pyrrolidin-3-yl]-2-(4-fluoro-phenyl)-N-methyl-acetamide was prepared from N-[(3RS,4SR)-4-(3,4-dichloro-phenyl)-pyrrolidin-3-yl]-2-(4-fluoro-phenyl)-N-methyl-acetamide using 6-morpholin-4-yl-pyridazine-3-carboxylic acid instead of 1-(1-methyl-cyclopropanecarbonyl)-piperidine-4-carboxylic acid and was obtained as a light yellow oil. MS m/e: 572.2 [M]+.

WORKUP

后处理

customIn analogy to the procedure described for the synthesis of example 87 (step c)
customwas obtained as a light yellow oil

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-3dd0a01e5fa84450a93e264f1e587705
来源数据集: uspto-grants-2013_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08404679B2
来源说明: uspto-grants-2013_03

反应 SMILES

[Cl:1][C:2]1[CH:3]=[C:4]([CH:9]2[CH2:13][NH:12][CH2:11][CH:10]2[N:14]([CH3:25])[C:15](=[O:24])[CH2:16][C:17]2[CH:22]=[CH:21][C:20]([F:23])=[CH:19][CH:18]=2)[CH:5]=[CH:6][C:7]=1[Cl:8].[N:26]1([C:32]2[N:37]=[N:36][C:35]([C:38](O)=[O:39])=[CH:34][CH:33]=2)[CH2:31][CH2:30][O:29][CH2:28][CH2:27]1>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:9]2[CH2:13][N:12]([C:38]([C:35]3[N:36]=[N:37][C:32]([N:26]4[CH2:31][CH2:30][O:29][CH2:28][CH2:27]4)=[CH:33][CH:34]=3)=[O:39])[CH2:11][CH:10]2[N:14]([CH3:25])[C:15](=[O:24])[CH2:16][C:17]2[CH:18]=[CH:19][C:20]([F:23])=[CH:21][CH:22]=2)[CH:5]=[CH:6][C:7]=1[Cl:8]