Tetrahydro-4H-pyran-4-one → HCID 67025679, compound

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Reaction Steps

In analogy to the procedure described for the synthesis of example 104, the title compound 4-chloro-N-{(3RS,4SR)-4-(4-chloro-phenyl)-1-[1-(tetrahydro-pyran-4-yl)-piperidine-4-carbonyl]-pyrrolidin-3-yl}-N-methyl-3-trifluoromethyl-benzamide was prepared from 4-chloro-N-[(3RS,4SR)-4-(4-chloro-phenyl)-1-(piperidine-4-carbonyl)-pyrrolidin-3-yl]-N-methyl-3-trifluoromethyl-benzamide using tetrahydro-4H-pyran-4-one instead of acetone and was obtained as a white foam. MS m/e: 612.2 [M]+.

Provenance & Evidence