Benzoyl isothiocyanate → N-Pyrazinylthiourea

Participants

Reaction Conditions

Reaction Steps

Aminopyrazine (2 g, 21.03 mmol) is dissolved in ethanol (20 ml) and benzoylisothiocyanate (2.82 ml) is added dropwise. The mixture is heated to 80° C. with stirring for 10 minutes then allowed to cool to room temperature. The solvent is removed in vacuo and the resulting solid dissolved in 1M sodium hydroxide (30 ml) and heated under reflux for 1 hour. The resultant suspension is filtered and the solid washed with water and a little cold methanol. The solid is dried in vacuo to yield the titled compound, m.p. 239-239.5° C., MH+ (AP+): 138 (M+—NH3). Other thioureas used are either commercially available or prepared in an analogous manner from the appropriate starting amine

Provenance & Evidence