Bromine → HCID 11254215, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of 1-pyridin-4-yl-propan-2-one (0.1 g, 0.812 mmol) in dioxane (7 ml) is added bromine (0.029 ml, 0.569 mmol) dropwise. After 45 minutes, the solvent is removed in vacuo and the crude product is dissolved in ethanol (15 ml). The solution is treated with pyrazin-2-yl-thiourea (0.125 g, 0.812 mmol) and the reaction mixture is heated at 60° C. for 3 hours. The solvent is removed in vacuo and purification by chromatography on silica, eluting with ethyl acetate-methanol affords the titled compound.

Provenance & Evidence