HCID 11254215, compound → [5-(2-Chloro-pyridin-4-yl)-4-methyl-thiazol-2-yl]-pyrazin-2-yl-amine

HRID 1951175Notes

Reaction equation

HRID 1951175 reaction equation
[CH3:1][C:2]1[N:3]=[C:4]([NH:13][C:14]2[CH:19]=[N:18][CH:17]=[CH:16][N:15]=2)[S:5][C:6]=1[C:7]1[CH:12]=[CH:11][N:10]=[CH:9][CH:8]=1.[Cl:20]C1C=C(CC(=O)C)C=CN=1>>[Cl:20][C:11]1[CH:12]=[C:7]([C:6]2[S:5][C:4]([NH:13][C:14]3[CH:19]=[N:18][CH:17]=[CH:16][N:15]=3)=[N:3][C:2]=2[CH3:1])[CH:8]=[CH:9][N:10]=1

Participants

3

Reactant 2

HCID 11254215HCID 11254215, compound2×HCID 82653143HCID 82653143, compound

Product 1

HCID 11301149[5-(2-Chloro-pyridin-4-yl)-4-methyl-thiazol-2-yl]-pyrazin-2-yl-amine

Procedure

The titled compound is prepared by an analogous procedure to (4-Methyl-5-pyridin-4-yl-thiazol-2-yl)-pyrazin-2-yl-amine (Example 1) by replacing 1-pyridin-4-yl-propan-2-one (1b) in this procedure with 1-(2-chloro-pyridin-4-yl)-propan-2-one.

Sources & evidence

ORD record
ord-670eea103daf4b76a2eb310de70b8359
Source dataset
uspto-grants-2013_03
Patent number
US08404684B2

Reaction notes

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