反应详情

To a stirred suspension of imidazole-1-carboxylic acid (4-methyl-5-pyridin-4-yl-thiazol-2-yl)-amide (example 18a) (0.15 g, 0.526 mmol) in dioxane (10 ml) is added 3-amino-N,N-dimethyl-propionamide (0.046 g, 0.526 mmol) in one portion. The reaction mixture is heated to reflux for 2 hours. The reaction mixture is allowed to cool to room temperature and the solvent is removed in vacuo. Trituration with ether/ethyl acetate yields the titled compound as a pale yellow solid.

1. temperatureThe reaction mixture is heated
2. temperatureto reflux for 2 hours
3. customthe solvent is removed in vacuo