Pyridine → HCID 32377207, compound

HRID 1951191Notes

Reaction equation

HRID 1951191 reaction equation
[CH3:1][C:2](=O)[CH2:3][C:4](=[O:6])[CH3:5].[CH3:8][O:9][C:10]1[CH:20]=[CH:19][C:13]([CH2:14][NH:15][C:16]([NH2:18])=[S:17])=[CH:12][CH:11]=1.N1C=CC=CC=1>CO>[CH3:8][O:9][C:10]1[CH:11]=[CH:12][C:13]([CH2:14][NH:15][C:16]2[S:17][C:3]([C:4](=[O:6])[CH3:5])=[C:2]([CH3:1])[N:18]=2)=[CH:19][CH:20]=1

Participants

5

Reactant 3

HCID 1049PyridineHCID 31261AcetylacetoneHCID 7669541-(4-Methoxybenzyl)-2-thiourea

Product 1

HCID 32377207HCID 32377207, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A stirred suspension of 3-chloro, 2,4-pentanedione (1.0 g, 7.43 mmol) and 1-(4-methoxy benzyl)-2-thiourea (1.46 g, 7.43 mmol) in methanol (10 ml) is treated with pyridine (0.6 ml). The reaction mixture is stirred at room temperature for 2 hours and then the solvent is removed in vacuo. The crude residue is triturated with ether to yield the titled compound as a white solid.

Workup

  1. customthe solvent is removed in vacuo
  2. customThe crude residue is triturated with ether

Sources & evidence

ORD record
ord-afc28e07e7bd4664a0c9e3d02bbbaeb5
Source dataset
uspto-grants-2013_03
Patent number
US08404684B2

Reaction notes

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