Cyclopropanecarboximidamide hydrochloride → N-[5-(2-Cyclopropyl-pyrimidin-4-yl)-4-methyl-thiazol-2-yl]-acetamide

HRID 1951196Notes

Reaction equation

[CH3:1][C:2]1[N:3]=[C:4]([NH:19][C:20](=[O:22])[CH3:21])[S:5][C:6]=1[C:7]1[CH:12]=[CH:11][N:10]=[C:9](N2CCOCC2)[N:8]=1.Cl.[CH:24]1(C(N)=N)[CH2:26][CH2:25]1>>[CH:24]1([C:9]2[N:8]=[C:7]([C:6]3[S:5][C:4]([NH:19][C:20](=[O:22])[CH3:21])=[N:3][C:2]=3[CH3:1])[CH:12]=[CH:11][N:10]=2)[CH2:26][CH2:25]1

Participants

Reactant 2

HCID 2781916Cyclopropanecarboximidamide hydrochloride

HCID 86610334N-[4-Methyl-5-(2-morpholin-4-yl-pyrimidin-4-yl)-thiazol-2-yl]-acetamide

Product 1

HCID 11231150N-[5-(2-Cyclopropyl-pyrimidin-4-yl)-4-methyl-thiazol-2-yl]-acetamide

Procedure

The titled compound is prepared by an analogous procedure to N-[4-Methyl-5-(2-morpholin-4-yl-pyrimidin-4-yl)-thiazol-2-yl]-acetamide (25e) by replacing morpholinoformamidine hydrobromide (part 25c) with cyclopropanecarboxamidine hydrochloride.

Sources & evidence

ORD record: ord-99162148547448ebb8ed4f2f4d0cb442
Source dataset: uspto-grants-2013_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08404684B2

Reaction notes

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