Thiourea → HCID 86653054, compound

HRID 1951201Notes

Reaction equation

HRID 1951201 reaction equation
[NH2:1][C:2]([NH2:4])=[S:3].Br[CH:6]([C:10]1[CH:15]=[CH:14][N:13]=[C:12]([Cl:16])[CH:11]=1)[C:7](=O)[CH3:8]>C(O)C>[Cl:16][C:12]1[CH:11]=[C:10]([C:6]2[S:3][C:2]([NH2:4])=[N:1][C:7]=2[CH3:8])[CH:15]=[CH:14][N:13]=1

Participants

4

Reactant 2

HCID 2723790ThioureaHCID 86653055HCID 86653055, compound

Product 1

HCID 86653054HCID 86653054, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
60 °C

Procedure

Thiourea (1.8 g, 29.4 mmol) is added to a stirred solution of 1-bromo-1-(2-chloro-pyridin-4-yl)-propan-2-one (7.3 g, 29.4 mmol) in ethanol (150 ml). The mixture is heated at 60° C. for 3 hours then allowed to cool to room temperature and stand for 18 h. The hydrobromide salt of the titled compound precipitates during this time and is removed by filtration and washed with diethyl ether.

Workup

  1. temperatureto cool to room temperature
  2. customThe hydrobromide salt of the titled compound precipitates during this time
  3. customis removed by filtration
  4. washwashed with diethyl ether

Sources & evidence

ORD record
ord-971d9961e7454c1b88b4996bfe252f74
Source dataset
uspto-grants-2013_03
Patent number
US08404684B2

Reaction notes

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