反应详情

温度

60 °C

Thiourea (1.8 g, 29.4 mmol) is added to a stirred solution of 1-bromo-1-(2-chloro-pyridin-4-yl)-propan-2-one (7.3 g, 29.4 mmol) in ethanol (150 ml). The mixture is heated at 60° C. for 3 hours then allowed to cool to room temperature and stand for 18 h. The hydrobromide salt of the titled compound precipitates during this time and is removed by filtration and washed with diethyl ether.

1. temperatureto cool to room temperature
2. customThe hydrobromide salt of the titled compound precipitates during this time
3. customis removed by filtration
4. washwashed with diethyl ether