Bromine → HCID 86653056, compound

HRID 1951204Notes

Reaction equation

HRID 1951204 reaction equation
[Br:1]Br.[CH3:3][C:4]1[N:9]=[C:8]([S:10][CH3:11])[N:7]=[C:6]([CH2:12][C:13](=[O:15])[CH3:14])[CH:5]=1>O1CCOCC1>[Br:1][CH:12]([C:6]1[CH:5]=[C:4]([CH3:3])[N:9]=[C:8]([S:10][CH3:11])[N:7]=1)[C:13](=[O:15])[CH3:14]

Participants

4

Reactant 2

HCID 24408BromineHCID 67200186HCID 67200186, compound

Product 1

HCID 86653056HCID 86653056, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Bromine (1.46 ml, 28.5 mmol) is added to a rapidly stirred cooled (5-10° C.) solution of 1-(6-methyl-2-methylsulfanyl-pyrimidin-4-yl)-propan-2-one (7.0 g, 35 mmol) in dioxane (100 ml) over 30 minutes. The reaction is allowed to warm to room temperature and the solvent is removed in vacuo to yield the titled compound which is used immediately in the next step.

Workup

  1. customthe solvent is removed in vacuo

Sources & evidence

ORD record
ord-6bb630f235ac48e9af09344c0f1c3328
Source dataset
uspto-grants-2013_03
Patent number
US08404684B2

Reaction notes

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