Thiourea → HCID 86610339, compound

Participants

Reaction Steps

Thiourea (2.7 g, 35 mmol) is added to a stirred solution of 1-bromo-1-(6-methyl-2-methylsulfanyl-pyrimidin-4-yl)-propan-2-one (AC3) in ethanol (100 ml) at 60° C. After 30 minutes the reaction is allowed to cool to room temperature. After standing for 18 hours the hydrobromide salt of the titled compound is removed by filtration and washed with diethyl ether. The product is dissolved in water and 2M sodium hydroxide is added to precipitate the titled compound as the free base.

Provenance & Evidence