HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzoyl isothiocyanate → [3-(3-Benzoyl-thioureido)-pyrazol-1-yl]-acetic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzoyl isothiocyanate | HCID 68284 | — |
| Reactant | tert-butyl 2-(3-amino-1H-pyrazol-1-yl)acetate | HCID 62111572 | — |
| Product | [3-(3-Benzoyl-thioureido)-pyrazol-1-yl]-acetic acid tert-butyl ester | HCID 86653059 | — |
Reaction Steps
(3-Amino-pyrazol-1-yl)-acetic acid tert-butyl ester (1.05 g, 5.33 mmol) is added dropwise under argon to a stirred solution of benzoyl isothiocyanate (0.754 ml, 5.4 mmol). After stirring for 5 minutes the reaction mixture is poured onto water and the titled compound, a yellow precipitate, is collected and dried.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08404684B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-80318661d54a4b2c9a81a5a3524f7f33 |
| Source note | uspto-grants-2013_03 |