tert-Butyl bromoacetate → HCID 86610341, compound

HRID 1951223Notes

Reaction equation

HRID 1951223 reaction equation
[NH:1]([C:5]1[CH:9]=[CH:8][N:7]([CH2:10][C:11](O)=O)[N:6]=1)[C:2]([NH2:4])=[S:3].BrC[C:16]([O:18]C(C)(C)C)=[O:17].C(OC(=O)CCBr)(C)(C)C>>[NH:1]([C:5]1[CH:9]=[CH:8][N:7]([CH2:10][CH2:11][C:16]([OH:18])=[O:17])[N:6]=1)[C:2]([NH2:4])=[S:3]

Participants

4

Reactant 3

HCID 79177tert-Butyl bromoacetateHCID 256128tert-Butyl 3-bromopropionateHCID 86610342HCID 86610342, compound

Product 1

HCID 86610341HCID 86610341, compound

Procedure

This material is prepared by an analogous procedure to (3-thioureido-pyrazol-1-yl)-acetic acid (intermediate DD) by replacing tert-butyl bromoacetate in step 2 with 3-bromo-propionic acid tert-butyl ester.

Sources & evidence

ORD record
ord-f221154620ca41cb8e1a1189c795f044
Source dataset
uspto-grants-2013_03
Patent number
US08404684B2

Reaction notes

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