Acetic Anhydride → HCID 11473512, compound

HRID 1951228Notes

Reaction equation

HRID 1951228 reaction equation
[NH2:1][C:2]1[S:3][C:4]([C:8]2[CH:13]=[C:12]([CH3:14])[N:11]=[C:10]([N:15]([CH3:21])[CH2:16][CH2:17][N:18]([CH3:20])[CH3:19])[N:9]=2)=[C:5]([CH3:7])[N:6]=1.[C:22](OC(=O)C)(=[O:24])[CH3:23]>>[CH3:20][N:18]([CH3:19])[CH2:17][CH2:16][N:15]([CH3:21])[C:10]1[N:9]=[C:8]([C:4]2[S:3][C:2]([NH:1][C:22](=[O:24])[CH3:23])=[N:6][C:5]=2[CH3:7])[CH:13]=[C:12]([CH3:14])[N:11]=1

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 86610343HCID 86610343, compound

Product 1

HCID 11473512HCID 11473512, compound

Procedure

N-[4-(2-Amino-4-methyl-thiazol-5-yl)-6-methyl-pyrimidin-2-yl]-N,N′,N′-trimethyl-ethane-1,2-diamine (0.020 g, 0.065 mmol) in acetic anhydride (1 ml) is heated at 60° C. for 2 hours. When cool, the solvent is removed in vacuo and the residue is partitioned between ethyl acetate (30 ml) and water (30 ml). The organic extract is removed, dried (MgSO4) and the solvent removed to give the titled compound.

Workup

  1. temperatureWhen cool
  2. customthe solvent is removed in vacuo
  3. customthe residue is partitioned between ethyl acetate (30 ml) and water (30 ml)
  4. extractionThe organic extract
  5. customis removed
  6. dry with materialdried (MgSO4)
  7. customthe solvent removed

Sources & evidence

ORD record
ord-2fcea40a87984deea69912b9d396be38
Source dataset
uspto-grants-2013_03
Patent number
US08404684B2

Reaction notes

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