(+-)-2-(Aminomethyl)-1-N-Boc-pyrrolidine → HCID 86653061, compound

HRID 1951232Notes

Reaction equation

HRID 1951232 reaction equation
[CH2:1]([C:3]1[O:7][C:6]([CH2:8][CH2:9][NH:10][C:11]([NH:13][C:14]2[S:15][C:16]([C:20]3[CH:25]=[C:24]([CH3:26])[N:23]=[C:22](S(C)=O)[N:21]=3)=[C:17]([CH3:19])[N:18]=2)=[O:12])=[N:5][CH:4]=1)[CH3:2].[C:30]([O:34][C:35]([N:37]1[CH2:41][CH2:40][CH2:39][CH:38]1[CH2:42][NH2:43])=[O:36])([CH3:33])([CH3:32])[CH3:31]>O1CCOCC1>[C:30]([O:34][C:35]([N:37]1[CH2:41][CH2:40][CH2:39][CH:38]1[CH2:42][NH:43][C:22]1[N:21]=[C:20]([C:16]2[S:15][C:14]([NH:13][C:11]([NH:10][CH2:9][CH2:8][C:6]3[O:7][C:3]([CH2:1][CH3:2])=[CH:4][N:5]=3)=[O:12])=[N:18][C:17]=2[CH3:19])[CH:25]=[C:24]([CH3:26])[N:23]=1)=[O:36])([CH3:33])([CH3:32])[CH3:31]

Participants

4

Reactant 2

HCID 2756484(+-)-2-(Aminomethyl)-1-N-Boc-pyrrolidineHCID 11281950HCID 11281950, compound

Product 1

HCID 86653061HCID 86653061, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

This material is prepared from 1-[2-(5-ethyl-oxazol-2-yl)-ethyl]-3-[5-(2-methanesulfinyl-6-methyl-pyrimidin-4-yl)-4-methyl-thiazol-2-yl]-urea (Example 40) and 2-aminomethyl-pyrrolidine-1-carboxylic acid tert-butyl ester by an analogous procedure to Example 42 but replacing DMF by dioxane.

Sources & evidence

ORD record
ord-54bb8ad0220d476f8b100fb37381b365
Source dataset
uspto-grants-2013_03
Patent number
US08404684B2

Reaction notes

Loading…