Sodium Methoxide → HCID 11406981, compound

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Reaction Steps

Sodium methoxide (2M in MeOH, 0.115 ml, 0.23 mmol) is added to a stirred solution of 1-[2-(5-ethyl-oxazol-2-yl)-ethyl]-3-[5-(2-methanesulfinyl-6-methyl-pyrimidin-4-yl)-4-methyl-thiazol-2-yl]-urea (Example 40) (0.050 g, 0.115 mmol) in methanol (3 ml) at room temperature. After 18 hours, the solvent is removed and the residue is dissolved in DCM and washed with water. The product is extracted into 1M HCl and the aqueous extract is washed with DCM. The aqueous phase is then basified with aq. NaOH and the product is extracted into DCM. After drying MgSO4) the solvent is removed to give the titled compound.

Provenance & Evidence