N-ethylhistamine → 1-[2-(1-Ethyl-1H-imidazol-4-yl)-ethyl]-3-[5-(2-methanesulfinyl-6-methyl-pyrimidin-4-yl)-4-methyl-thiazol-2-yl]-urea

HRID 1951235Notes

Reaction equation

HRID 1951235 reaction equation
[CH3:1][S:2]([C:4]1[N:9]=[C:8]([C:10]2[S:14][C:13]([NH:15][C:16]([N:18]3[CH:22]=[CH:21]N=C3)=[O:17])=[N:12][C:11]=2[CH3:23])[CH:7]=[C:6]([CH3:24])[N:5]=1)=[O:3].[CH2:25]([N:27]1[CH:31]=[C:30](CCN)[N:29]=[CH:28]1)[CH3:26]>>[CH2:25]([N:27]1[CH:31]=[C:30]([CH2:21][CH2:22][NH:18][C:16]([NH:15][C:13]2[S:14][C:10]([C:8]3[CH:7]=[C:6]([CH3:24])[N:5]=[C:4]([S:2]([CH3:1])=[O:3])[N:9]=3)=[C:11]([CH3:23])[N:12]=2)=[O:17])[N:29]=[CH:28]1)[CH3:26]

Participants

3

Reactant 2

HCID 44292270N-ethylhistamineHCID 86610344Imidazole-1-carboxylic acid [5-(2-methanesulfinyl-6-methyl-pyrimidin-4-yl)-4-methyl-thiazol-2-yl]-amide

Product 1

HCID 111663941-[2-(1-Ethyl-1H-imidazol-4-yl)-ethyl]-3-[5-(2-methanesulfinyl-6-methyl-pyrimidin-4-yl)-4-methyl-thiazol-2-yl]-urea

Procedure

This compound is prepared from imidazole-1-carboxylic acid [5-(2-methanesulfinyl-6-methyl-pyrimidin-4-yl)-4-methyl-thiazol-2-yl]-amide (imidazole-urea intermediate BD) and 2-(1-ethyl-1H-imidazol-4-yl)-ethylamine (thiourea intermediate CC1) using general procedure A.

Sources & evidence

ORD record
ord-ffd99e11b5364fe48d9b7af9593587b2
Source dataset
uspto-grants-2013_03
Patent number
US08404684B2

Reaction notes

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