HCID 11259470, compound → HCID 86610345, compound

HRID 1951237Notes

Reaction equation

[CH:1]([N:4]1C=C(CCNC(NC2SC(C3C=C(C)N=C(SC)N=3)=C(C)N=2)=O)N=[CH:5]1)([CH3:3])[CH3:2].C(C1O[C:35]([CH2:37][CH2:38][NH:39][C:40]([NH:42][C:43]2[S:44][C:45]([C:49]3[CH:54]=[C:53]([CH3:55])[N:52]=[C:51]([S:56]([CH3:59])(=[O:58])=[O:57])[N:50]=3)=[C:46]([CH3:48])[N:47]=2)=[O:41])=[N:34][CH:33]=1)C>>[CH:1]([N:4]1[CH:5]=[C:35]([CH2:37][CH2:38][NH:39][C:40]([NH:42][C:43]2[S:44][C:45]([C:49]3[CH:54]=[C:53]([CH3:55])[N:52]=[C:51]([S:56]([CH3:59])(=[O:57])=[O:58])[N:50]=3)=[C:46]([CH3:48])[N:47]=2)=[O:41])[N:34]=[CH:33]1)([CH3:3])[CH3:2]

Participants

Reactant 2

HCID 11259470HCID 11259470, compound

HCID 86653063HCID 86653063, compound

Product 1

HCID 86610345HCID 86610345, compound

Procedure

This material is prepared from 1-[2-(1-isopropyl-1H-imidazol-4-yl)-ethyl]-3[4-methyl-5-(6-methyl-2-methylsulfanyl-pyrimidin-4-yl)-thiazol-2-yl]-urea by the same protocol described for 1-[2-(5-ethyl-oxazol-2-yl)-ethyl]-3-[5-(2-methanesulfonyl-6-methyl-pyrimidin-4-yl)-4-methyl-thiazol-2-yl]-urea (Example 41).

Sources & evidence

ORD record: ord-bb6e5af6b5b5487a9765e8a604c5b2d7
Source dataset: uspto-grants-2013_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08404684B2

Reaction notes

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