Acetic Anhydride → HCID 11289280, compound

HRID 1951240Notes

Reaction equation

HRID 1951240 reaction equation
[C:1]([C:5]1[N:10]=[C:9]([C:11]2[S:15][C:14]([NH2:16])=[N:13][C:12]=2[CH3:17])[CH:8]=[CH:7][N:6]=1)([CH3:4])([CH3:3])[CH3:2].[C:18](OC(=O)C)(=[O:20])[CH3:19].CN(C)CCN(C)C1N=C(C2SC(NC(=O)C)=NC=2C)C=C(C)N=1>>[C:1]([C:5]1[N:10]=[C:9]([C:11]2[S:15][C:14]([NH:16][C:18](=[O:20])[CH3:19])=[N:13][C:12]=2[CH3:17])[CH:8]=[CH:7][N:6]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 3

HCID 7918Acetic AnhydrideHCID 11425177HCID 11425177, compoundHCID 11473512HCID 11473512, compound

Product 1

HCID 11289280HCID 11289280, compound

Procedure

This material is prepared by acylating 5-(2-tert-Butyl-pyrimidin-4-yl)-4-methyl-thiazol-2-ylamine (Intermediate AG) with acetic anhydride as described for N-(5-{2-[(2-dimethylamino-ethyl)-methyl-amino]-6-methyl-pyrimidin-4-yl}-4-methyl-thiazol-2-yl)-acetamide (Example 39, step 2).

Workup

  1. customThis material is prepared

Sources & evidence

ORD record
ord-9414810cb4484955a00cebf41d7411b5
Source dataset
uspto-grants-2013_03
Patent number
US08404684B2

Reaction notes

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