1,1'-Carbonyldiimidazole → HCID 59185796, compound

Participants

Reaction Conditions

Reaction Steps

4-Acetyl-3,5-dimethylpyrrole carboxylic acid (15.731 g, 86.82 mmol), was taken up in anhydrous DMF (40 mL) and cooled to 0° C. Carbonyldiimidazole (14.512 g, 86.82 mmol) was added to this slurry and stirred until the evolution of gas ceased and a clear solution formed. 2-Chloroethyl amine hydrochloride (10.574 g, 91.16 mmol) was added in one portion. The reaction mixture was left to stir overnight at room temperature. The reaction mixture was extracted in water (50 mL) from DCM (4×20 mL). The aqueous layer (containing precipitate) was filtered off and washed with cold water. The white solid was found to be the target compound. (10.316 g, 42.51 mmol, 49% yield).

Provenance & Evidence