2-Methoxyethylamine → HCID 59185795, compound

Participants

Reaction Steps

A solution of the pyrimidine acid Example I-70 {4-[4-(6,8-dimethyl-1-oxo-1,2,3,4-tetrahydro-pyrrolo[1,2-a]pyrazin-7-yl)-pyrimidin-2-ylamino]-phenyl}-acetic acid (0.05 g), EDCI (1.2 eq., 0.028 g) and HOBt (1.2 eq., 0.02 g) in THF (3 mL) was stirred at room temperature under nitrogen for 1 hour. 2-Methoxyethylamine (1.2 eq., 0.013 mL) was then added and the resulting reaction stirred at room temperature for 16 hours. Water (5 mL) was added and the solvent removed under vacuum to leave an aqueous suspension which was extracted with dichloromethane (2×2 mL). The combined organics were stripped to yield the crude product as a yellow oil (0.0656 g). Purification of the crude material (prep. HPLC) produced the title compound as a white solid (0.0269 g, 47%, with a purity of 98.37% by LCMS.

Provenance & Evidence