O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate → HCID 16665422, compound

HRID 1951250Notes

Reaction equation

HRID 1951250 reaction equation
[CH3:1][C:2]1[N:6]2[CH2:7][CH2:8][NH:9][C:10](=[O:11])[C:5]2=[C:4]([CH3:12])[C:3]=1[C:13]1[CH:18]=[CH:17][N:16]=[C:15]([NH:19][C:20]2[CH:28]=[CH:27][C:23](C(O)=O)=[CH:22][C:21]=2OC)[N:14]=1.N[CH:32]1C[CH2:36][N:35]([CH3:38])[CH2:34][CH2:33]1.CN(C([O:46]N1N=NC2C=CC=CC1=2)=[N+](C)C)C.[B-](F)(F)(F)F>>[CH3:1][C:2]1[N:6]2[CH2:7][CH2:8][NH:9][C:10](=[O:11])[C:5]2=[C:4]([CH3:12])[C:3]=1[C:13]1[CH:18]=[CH:17][N:16]=[C:15]([NH:19][C:20]2[CH:28]=[C:27]([CH2:32][CH2:33][C:34]([N:35]([CH3:38])[CH3:36])=[O:46])[CH:23]=[CH:22][CH:21]=2)[N:14]=1

Participants

4

Reactant 3

HCID 2733207O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 27375314-Amino-1-methylpiperidineHCID 16666274HCID 16666274, compound

Product 1

HCID 16665422HCID 16665422, compound

Procedure

By reaction of Example I-27 4-[4-(6,8-Dimethyl-1-oxo-1,2,3,4-tetrahydro-pyrrolo[1,2-a]pyrazin-7-yl)-pyrimidin-2-ylamino]-3-methoxy-benzoic acid and 4-amino-1-methylpiperidine as described above but using TBTU as the coupling agent.

Sources & evidence

ORD record
ord-8a0be1fe0a3846a1a6b7388305669120
Source dataset
uspto-grants-2013_03
Patent number
US08404692B2

Reaction notes

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