O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate → HCID 59185788, compound

HRID 1951251Notes

Reaction equation

HRID 1951251 reaction equation
[CH3:1][C:2]1[N:6]2[CH2:7][CH2:8][NH:9][C:10](=[O:11])[C:5]2=[C:4]([CH3:12])[C:3]=1[C:13]1[CH:18]=[CH:17][N:16]=[C:15]([NH:19][C:20]2[CH:28]=[CH:27][C:23]([C:24]([OH:26])=O)=[CH:22][CH:21]=2)[N:14]=1.[NH2:29][CH:30]1[CH2:35][CH2:34][N:33]([CH3:36])[CH2:32][CH2:31]1.CN([C:40]([O:44]N1N=NC2C=CC=CC1=2)=[N+](C)C)C.[B-](F)(F)(F)F>>[CH3:1][C:2]1[N:6]2[CH2:7][CH2:8][NH:9][C:10](=[O:11])[C:5]2=[C:4]([CH3:12])[C:3]=1[C:13]1[CH:18]=[CH:17][N:16]=[C:15]([NH:19][C:20]2[CH:21]=[CH:22][C:23]([C:24]([NH:29][CH:30]3[CH2:35][CH2:34][N:33]([CH3:36])[CH2:32][CH2:31]3)=[O:26])=[CH:27][C:28]=2[O:44][CH3:40])[N:14]=1

Participants

4

Reactant 3

HCID 2733207O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 27375314-Amino-1-methylpiperidineHCID 16666273HCID 16666273, compound

Product 1

HCID 59185788HCID 59185788, compound

Procedure

By reaction of Example I-26 4-[4-(6,8-dimethyl-1-oxo-1,2,3,4-tetrahydro-pyrrolo[1,2-a]pyrazin-7-yl)-pyrimidin-2-ylamino]-benzoic acid and 4-amino-1-methylpiperidine as described above but using TBTU as the coupling agent.

Sources & evidence

ORD record
ord-8fb6f7d74c7043f5ad87ffcda777b71b
Source dataset
uspto-grants-2013_03
Patent number
US08404692B2

Reaction notes

Loading…