HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Bromo-3-methylthiophenecarboxylic acid → 4-Bromo-N-(5-(cyclopropylcarbamoyl)-2-methylphenyl)-3-methylthiophene-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Bromo-3-methylthiophenecarboxylic acid | HCID 2757073 | — |
| Reactant | 3-Amino-N-cyclopropyl-4-methylbenzamide hydrochloride | HCID 44203194 | — |
| Product | 4-Bromo-N-(5-(cyclopropylcarbamoyl)-2-methylphenyl)-3-methylthiophene-2-carboxamide | HCID 59761512 | — |
Reaction Steps
The compound a was prepared by coupling commercially available 4-bromo-3-methylthiophene-2-carboxylic acid with 3-amino-N-cyclopropyl-4-methylbenzamide hydrochloride (prepared as described in WO 04/071440) using the method described in Example 128. HPLC Ret time=3.12 min. LCMS [M+H]+ 393.13.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08404689B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-080b5d3829454cc69072f9a44d8f5b8e |
| Source note | uspto-grants-2013_03 |