HuagongsheHuagongshe Chemistry Print Report · For research reference only
(6-Fluoropyridin-3-yl)boronic acid → N-(5-(Cyclopropylcarbamoyl)-2-methylphenyl)-4-(6-fluoropyridin-3-yl)-3-methylthiophene-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (6-Fluoropyridin-3-yl)boronic acid | HCID 2783397 | — |
| Reactant | 4-Bromo-N-(5-(cyclopropylcarbamoyl)-2-methylphenyl)-3-methylthiophene-2-carboxamide | HCID 59761512 | — |
| Product | N-(5-(Cyclopropylcarbamoyl)-2-methylphenyl)-4-(6-fluoropyridin-3-yl)-3-methylthiophene-2-carboxamide | HCID 24985754 | — |
Reaction Steps
The title compound was prepared by coupling 4-bromo-N-(5-(cyclopropylcarbamoyl)-2-methylphenyl)-3-methylthiophene-2-carboxamide with commercially available 6-fluoropyridin-3-ylboronic acid using the method described in Step B of Example 136 to afford a white solid (Example 199). HPLC Ret time=2.98 min. LCMS [M+H]+ 410.25.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08404689B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-d2e01e66774643a9815934cb222c9213 |
| Source note | uspto-grants-2013_03 |