HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Bromothiophene-3-carboxylic acid → 5-Bromo-N-(5-(cyclopropylcarbamoyl)-2-methylphenyl)thiophene-3-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Bromothiophene-3-carboxylic acid | HCID 12039978 | — |
| Reactant | 3-Amino-N-cyclopropyl-4-methylbenzamide hydrochloride | HCID 44203194 | — |
| Product | 5-Bromo-N-(5-(cyclopropylcarbamoyl)-2-methylphenyl)thiophene-3-carboxamide | HCID 59761487 | — |
Reaction Steps
Compound a was prepared by coupling commercially available 5-bromothiophene-3-carboxylic acid with 3-amino-N-cyclopropyl-4-methylbenzamide hydrochloride (prepared as described in WO 04/071440) using the method described in Example 128 to afford a tan solid. HPLC Ret time=3.02 min. LCMS [M+H]+ 379.0.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08404689B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-a6b723ece33a4f15818b262de1c71639 |
| Source note | uspto-grants-2013_03 |