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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1951266Generated: November 4, 2026

4-Chlorophenylboronic acid → 5-(4-Chlorophenyl)-N-(5-(cyclopropylcarbamoyl)-2-methylphenyl)thiophene-3-carboxamide

https://huagongshe.com/reaction/1951266

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Chlorophenylboronic acidHCID 74299—
Reactant5-Bromo-N-(5-(cyclopropylcarbamoyl)-2-methylphenyl)thiophene-3-carboxamideHCID 59761487—
Product5-(4-Chlorophenyl)-N-(5-(cyclopropylcarbamoyl)-2-methylphenyl)thiophene-3-carboxamideHCID 24985911—

Reaction Steps

The title compound was prepared by coupling 5-bromo-N-(5-(cyclopropylcarbamoyl)-2-methylphenyl)thiophene-3-carboxamide a with commercially available 4-chlorophenylboronic acid using the method described in Step B of Example 136 to afford a white solid (Example 201). HPLC Ret time=3.67 min. LCMS [M+H]+ 411.21.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08404689B2
Source datasetuspto-grants-2013_03
ORD IDord-d374323fdedc4afdb3f9ed8dfda47674
Source noteuspto-grants-2013_03