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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1951267Generated: November 3, 2026

5-Bromo-N-(5-(cyclopropylcarbamoyl)-2-methylphenyl)thiophene-3-carboxamide → N-(5-(Cyclopropylcarbamoyl)-2-methylphenyl)-5-(pyridin-3-yl)thiophene-3-carboxamide

https://huagongshe.com/reaction/1951267

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-Bromo-N-(5-(cyclopropylcarbamoyl)-2-methylphenyl)thiophene-3-carboxamideHCID 59761487—
Reactant3-Pyridylphenylboronic acidHCID 66725065—
ProductN-(5-(Cyclopropylcarbamoyl)-2-methylphenyl)-5-(pyridin-3-yl)thiophene-3-carboxamideHCID 24985912—

Reaction Steps

The title compound was prepared by coupling 5-bromo-N-(5-(cyclopropylcarbamoyl)-2-methylphenyl)thiophene-3-carboxamide with commercially available 3-pyridylphenylboronic acid using the method described in Step B of Example 136 to afford a white solid (Example 202). HPLC Ret time=1.97 min. LCMS [M+H]+ 378.2.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08404689B2
Source datasetuspto-grants-2013_03
ORD IDord-7b8a460fcb604a48b80717bf1862918e
Source noteuspto-grants-2013_03