HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Bromo-2-thiophenecarboxylic Acid → 4-Bromo-N-(5-(cyclopropylcarbamoyl)-2-methylphenyl)thiophene-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Bromo-2-thiophenecarboxylic Acid | HCID 610409 | — |
| Reactant | 3-Amino-N-cyclopropyl-4-methylbenzamide hydrochloride | HCID 44203194 | — |
| Product | 4-Bromo-N-(5-(cyclopropylcarbamoyl)-2-methylphenyl)thiophene-2-carboxamide | HCID 59761499 | — |
Reaction Steps
Compound a was prepared by coupling commercially available 3-bromothiophene-5-carboxylic acid with 3-amino-N-cyclopropyl-4-methylbenzamide hydrochloride (prepared as described in WO 04/071440) using the method described in Example 128 to afford a tan solid. HPLC Ret time=3.01 min. LCMS [M+H]+ 379.0.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08404689B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-61bf9919d9a2467f8480d43c25c02100 |
| Source note | uspto-grants-2013_03 |