Ammonium formate → HCID 178515402, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of N-(4-(2-(allyloxy)pyrazolo[1,5-a]pyrimidin-7-ylthio)phenyl)-4-(4-chlorophenyl)phthalazin-1-amine (0.110 g, 0.20 mmol, Example 4) and ammonium formate (130 mg, 2.0 mmol) in MeOH (7 mL) was added a slurry of 10% palladium on carbon, (44 mg) in EtOAc (1 mL). The mixture was heated to 65° C. After 8 hrs, the mixture was cooled to RT, filtered over celite, concentrated in vacuo, and purified by silica gel chromatography using 5-15% MeOH in CH2Cl2 with 1% NH4OH to afford 7-(4-(4-(4-chlorophenyl)phthalazin-1-ylamino)phenylthio)pyrazolo[1,5-a]pyrimidin-2-ol as a light yellow solid. MS: Found M+H+=497.0.

Provenance & Evidence