HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hexane → HCID 10065431, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hexane | HCID 8058 | — |
| Reactant | Tris(1,1-dimethylethyl)phosphine | HCID 83681 | — |
| Reactant | HCID 10045213 | HCID 10045213 | — |
| Reactant | sodium 2-methylpropan-2-olate | HCID 178418730 | — |
| Catalyst | palladium(II) acetate | HCID 167845 | — |
| Product | HCID 10065431 | HCID 10065431 | — |
Reaction Steps
Similar to the preparation of the compound of Example 13, the title compound is made from the reaction of Pd(OAc)2 (1.34 mg, 0.006 mmol), 10% solution of P(t-Bu)3 in hexane (0.015 ml, 0.0048 mmol), and NaO-t-Bu (86.4 g, 0.9 mmol) in the presence of argon and then a solution of (+)-3-methoxy-morphinan (0.1645 g, 0.5 mmol) and bromobenzene (0.094 g, 0.6 mmol) in toluene (˜12 mL).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08404706B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-1354ce98d1a94db4a5a1aa7086542ccd |
| Source note | uspto-grants-2013_03 |