HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Bromide → 2-Methylimidazo[1,2-a]pyridine-8-carbaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Bromide | HCID 253877 | — |
| Reactant | 2-Methylimidazo[1,2-a]pyridine-8-methanol | HCID 13900330 | — |
| Product | 2-Methylimidazo[1,2-a]pyridine-8-carbaldehyde | HCID 13900241 | 98% |
Reaction Steps
From 3b: reaction time 3 h: (yield: 98%); mp 123-125° C. (in Kaminski, J. J. and al. J. Med. Chem. 1989, 32, 1686-1700: 140-143° C.); IR (KBr) 1690, 1315 cm−1; 1H NMR (400 MHz, CDCl3) δ 2.49 (s, 3H), 6.86 (t, 1H, J=7 Hz), 7.44 (s, 1H), 7.71 (d, 1H, J=7 Hz), 8.26 (d, 1H, J=7 Hz), 10.66 (s, 1H); 13C NMR (100 MHz, CDCl3) δ 14.5, 110.1, 111.2, 123.2, 126.2, 130.0, 143.6, 145.2, 189.0; MS m/z 160 (M+, 30), 132 (100), 131 (49), 105 (25), 92 (22), 51 (20).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08404707B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-4b6a7185e6054af1b9f5bcd6a8b6f74b |
| Source note | uspto-grants-2013_03 |