Acetic Acid → HCID 67417445, compound

Participants

Reaction Steps

300 mg (1.59 mmol) of 2-methyl-4-oxo-4H-chromene-8-carbaldehyde are dissolved with 167.5 mg (1.59 mmol) of sodium 1-cyanoprop-1-en-2-olate, 175 mg (1.59 mmol) of 4-aminopyridin-2(1H)-one [Searls, T., McLaughlin, L. W., Tetrahedron 55, 11985-11996 (1999)] and 137 μl (2.39 mmol) of acetic acid in 12 ml of 2-propanol and heated under reflux under argon for 12 h. After cooling, the reaction mixture is filtered and the remaining solid is washed with diethyl ether (20 ml). 454 mg (82% of theory) of the title compound are obtained as a white solid.

Provenance & Evidence