HCID 54049649, compound → 3-Ethyl-4-formylbenzonitrile

HRID 1951383Notes

Reaction equation

HRID 1951383 reaction equation
[CH:1]([C:3]1[CH:10]=[CH:9][C:6]([C:7]#[N:8])=[CH:5][C:4]=1[CH:11]=[CH2:12])=[O:2]>C(O)C.[Pd]>[CH2:11]([C:4]1[CH:5]=[C:6]([CH:9]=[CH:10][C:3]=1[CH:1]=[O:2])[C:7]#[N:8])[CH3:12]

Participants

4

Reactant 1

HCID 54049649HCID 54049649, compound

Product 1

HCID 178193273-Ethyl-4-formylbenzonitrile

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of 1.3 g (8.27 mmol) of 4-formyl-3-vinylbenzonitrile in 35 ml of ethanol is mixed with 880 mg of 10% palladium on carbon and vigorously stirred under a hydrogen atmosphere for 2 h. The suspension is filtered through a layer of kieselguhr, the residue is washed with ethanol, and the filtrate is concentrated. The residue (890 mg) is employed without further purification in the following stage.

Workup

  1. filtrationThe suspension is filtered through a layer of kieselguhr
  2. washthe residue is washed with ethanol
  3. concentrationthe filtrate is concentrated
  4. customThe residue (890 mg) is employed without further purification in the following stage

Sources & evidence

ORD record
ord-5961038d2ff14dfcb0fe4c3b12a1ab8c
Source dataset
uspto-grants-2013_03
Patent number
US08404709B2

Reaction notes

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