Methanol → 3-Acetyl-2-methyl-4-(2-methyl-4-oxo-4H-chromen-8-yl)-1,4-dihydro-1,6-naphthyridin-5-yl ethane-sulfonate

Participants

Reaction Steps

133 mg (0.367 mmol) of 3-acetyl-2-methyl-4-(2-methyl-4-oxo-4H-chromen-8-yl)-4,6-dihydro-1,6-naphthyridin-5(1H)-one are suspended in pyridine (5 ml), and 700 (0.73 mmol) of ethanesulfonyl chloride are added. The suspension is stirred at RT for 3 h (during which the precursor dissolves), and then mixed with methanol and concentrated. The residue is purified by preparative HPLC to result in 63 mg (43% of theory) of the title compound as a white solid.

Provenance & Evidence