Methanesulfonyl chloride → HCID 24798420, compound

HRID 1951408Notes

Reaction equation

HRID 1951408 reaction equation
[C:1]([C:4]1[CH:13]([C:14]2[CH:15]=[CH:16][CH:17]=[C:18]3[C:23]=2[O:22][C:21]([CH3:24])=[CH:20][C:19]3=[O:25])[C:12]2[C:11](=[O:26])[NH:10][CH:9]=[CH:8][C:7]=2[NH:6][C:5]=1[CH3:27])(=[O:3])[CH3:2].[CH3:28][S:29](Cl)(=[O:31])=[O:30]>>[CH3:28][S:29]([O:26][C:11]1[N:10]=[CH:9][CH:8]=[C:7]2[C:12]=1[CH:13]([C:14]1[CH:15]=[CH:16][CH:17]=[C:18]3[C:23]=1[O:22][C:21]([CH3:24])=[CH:20][C:19]3=[O:25])[C:4]([C:1](=[O:3])[CH3:2])=[C:5]([CH3:27])[NH:6]2)(=[O:31])=[O:30]

Participants

3

Reactant 2

HCID 31297Methanesulfonyl chlorideHCID 596030093-Acetyl-2-methyl-4-(2-methyl-4-oxo-4H-chromen-8-yl)-4,6-dihydro-1,6-naphthyridin-5(1H)-one

Product 1

HCID 24798420HCID 24798420, compound

Procedure

The title compound is prepared in analogy to example 10 from 50 mg (0.13 mmol) of 3-acetyl-2-methyl-4-(2-methyl-4-oxo-4H-chromen-8-yl)-4,6-dihydro-1,6-naphthyridin-5(1H)-one and 12 μl (0.15 mmol) of methanesulfonyl chloride. 10.4 mg (15% of theory) of the product are obtained as a pale yellow solid.

Workup

  1. custom10.4 mg (15% of theory) of the product are obtained as a pale yellow solid

Sources & evidence

ORD record
ord-8e51e46dd59d456ca2446b46073e3d4e
Source dataset
uspto-grants-2013_03
Patent number
US08404709B2

Reaction notes

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