HCID 59492358, compound → HCID 59492344, compound

HRID 1951541Notes

Reaction equation

HRID 1951541 reaction equation
[CH3:1][C:2]1[CH:3]=[N:4][C:5]2[C:10]([CH:11]=1)=[C:9]([CH2:12][OH:13])[CH:8]=[CH:7][CH:6]=2>ClCCl.[O-2].[Mn+4].[O-2]>[CH3:1][C:2]1[CH:3]=[N:4][C:5]2[CH:6]=[CH:7][CH:8]=[C:9]([CH:12]=[O:13])[C:10]=2[CH:11]=1

Participants

4

Reactant 1

HCID 59492358HCID 59492358, compound

Product 1

HCID 59492344HCID 59492344, compound

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 6344DichloromethaneSolvent

Procedure

30.0 g (173 mmol) of the compound from example 22A are taken up in 850 ml of dichloromethane, and 240.0 g of manganese(IV) oxide are added. The mixture is stirred at room temperature for 16 h and then filtered through kieselguhr. The latter is washed with dichloromethane, and the filtrate is concentrated in a rotary evaporator. Drying the residue results in 23.0 g (75% of theory) of the title compound.

Workup

  1. filtrationfiltered through kieselguhr
  2. washThe latter is washed with dichloromethane
  3. concentrationthe filtrate is concentrated in a rotary evaporator
  4. customDrying the residue

Sources & evidence

ORD record
ord-0d179d656c42411d9a2b62c2b1fd5e04
Source dataset
uspto-grants-2013_03
Patent number
US08404723B2

Reaction notes

Loading…