(2Z)-3-Amino-2-butenenitrile → HCID 135844963, compound

Participants

Reaction Steps

100 mg (0.620 mmol) of the compound from example 3A, 114 mg (0.620 mmol) of the compound from example 12A and 51 mg (0.620 mmol) of 3-aminocrotononitrile are dissolved in 4 ml of isopropanol and stirred at the reflux temperature overnight. After cooling to room temperature, the volatile components are removed in a rotary evaporator, and the crude product is purified by preparative HPLC (eluent: acetonitrile/water with 0.1% formic acid, gradient 20:80→95:5). 134 mg (66% of theory) of the title compound are obtained.

Provenance & Evidence