2-Bromobenzaldehyde → 4-(2-Bromophenyl)-2,6-dimethyl-5-(4-methyl-1,3-thiazol-2-yl)-1,4-dihydropyridine-3-carbonitrile

Participants

Reaction Steps

150 mg (0.811 mmol) of 2-bromobenzaldehyde, 126 mg (0.811 mmol) of the compound from example 4A and 67 mg (0.811 mmol) of 3-aminocrotononitrile are dissolved in 4 ml of isopropanol and stirred at the reflux temperature overnight. After cooling to room temperature, the volatile components are removed in a rotary evaporator, the crude material is taken up in 5 ml of ethyl acetate, and the precipitated product is then filtered off 190 mg (61% of theory) of the title compound are obtained.

Provenance & Evidence