2-Chloro-4-fluorobenzaldehyde → HCID 135844967, compound

Participants

Reaction Steps

150 mg (0.946 mmol) of 2-chloro-4-fluorobenzaldehyde, 147 mg (0.811 mmol) of the compound from example 4A and 78 mg (0.811 mmol) of 3-aminocrotononitrile are dissolved in 4 ml of isopropanol and stirred at the reflux temperature overnight. After cooling to room temperature, the volatile components are removed in a rotary evaporator, the crude material is taken up in 5 ml of ethyl acetate, and the precipitated product is then filtered off 199 mg (58% of theory) of the title compound are obtained.

Provenance & Evidence