(2Z)-3-Amino-2-butenenitrile → HCID 24800075, compound

Participants

Reaction Steps

150 mg (0.931 mmol) of the compound from example 3A, 181 mg (0.931 mmol) of the compound from example 19A and 76 mg (0.931 mmol) of 3-aminocrotononitrile are dissolved in 4 ml of isopropanol and stirred at the reflux temperature overnight. After cooling to room temperature, the volatile components are removed in a rotary evaporator, and the crude product is taken up in 3 ml of ethyl acetate. The crystallizing solid is removed by filtration. The precipitate obtained in this way is washed with hot acetonitrile and dried under high vacuum. 131 mg (35% of theory) of the title compound are obtained.

Provenance & Evidence